Neurologia

Neurodegenerative Disorders provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions including Alzheimer Disease; Dementia and Cerebrovascular Disease; Parkinson's Disease; Fronto-Temporal Dementia; Amyotrophic Lateral Sclerosis; Huntington's Disease; Parkinsonism Plus syndromes and Prion Diseases. Final chapters cover important management issues including the use of palliative care strategies, advance directives and competence. Written by experts in the field internationally Neurodegenerative Disorders is a practical guide for clinicians that will be indispensable for the management of these conditions.

The volume includes 75 papers which were presented at the Third International Conference on Intracerebral Hemorrhage, held in Rancho Mirage, California, in March 2010. The topics treated include animal models, pathophysiology of cerebral hemorrhage, experimental treatment for cerebral hemorrhage, cerebral hemorrhage clinical manifestations, prognosis of cerebral hemorrhage, and clinical management. The articles represent the recent advances in hemorrhagic brain injury research presented by highly respected laboratories around the world.

Without a doubt, this atlas will become an iindispensible tool for teaching temporal bone dissection and training competent and confident otolaryngological surgeons. -- Annals of Otology, Rhinology, & Laryngology Temporal Bone Dissection Guide elucidates the key concepts of otologic surgery in a user-friendly manner that is refreshingly accessible to beginning surgeons. Users are provided with only the most relevant information to ensure they are not distracted from the mail goal -- to hone their surgical skills so as to mature into safe and effective temporal bone surgeons. The organization of this highly visual guidebook is designed to teach users to confidently navigate the complex anatomy of the temporal bone and to visualize the surgical steps within a clinical context. Concise descriptions of procedure, anatomy, and surgical objectives are accompanied by clearly labeled image sequences. Features: *141 detailed, high-quality drawings depict each surgical step * Histologic sections and CT images illustrate the intricate anatomic relationships within the temporal bone * A convenient lay-flat wire binding facilitates easy reference in the lab * Invaluable advice from the experts, including tips on precisely how to sculpt cortical planes, the technical nuances of the mastoidectomy, and much more The ideal companion in the temporal bone lab, this step-by-step guide will provide residents in otolaryngology--head and neck surgery and skull base surgery with a firm grasp of the basics. It is also an effective tool for specialists who need to refresh their dissection skills.

This is an excellent book and a needed update. For anyone interested in studying this specific neoplasm in depth,this book is worthwhile. It is a must-have in all neurosurgery, neurology, and radiology libraries. -- Doody's Review Al-Mefty's Meningiomas, Second Edition is the definitive guide to meningioma diagnosis, treatment, and surgery, and reflects over a decade of major advances in the diagnosis and management of both intracranial and spinal meningiomas since the first edition was published. Features: * New to this edition: information on molecular biology, natural history and growth rates, the rise of radiosurgery as a viable treatment option, and much more * Over 500 high-quality radiographic images and full-color illustrations demonstrate anatomy and surgery * In-depth coverage of intraoperative MRI and endoscopic resection * Key topics often missing from other meningiomas texts including caseload management, and postoperative quality of life issues This landmark reference will enhance the precision and surgical skills of every clinician or resident in neurosurgery or neurology.

Research into the neuropsychiatry of epilepsy has become a central focus of interest in the last five years. Comorbidity of epilepsy with behavioral problems is now recognized widely, and the neuroscientific basis for such comorbidity is an active area of investigation. With an expanded international team of authors, this fully revised new edition builds on the strengths of its predecessor, examining in detail the subtleties of behavioral changes in patients with seizure disorders and offering both a diagnostic and a management perspective. New chapters cover genetic disorders, the effects of epilepsy on social behavior as viewed through theory of mind, a discussion of the precuneus, the importance and nature of peri-ictal psychiatric symptoms, depression and the interictal dysphoric disorder, and the relationship between antiepileptic drugs and suicide. This new edition is a must for anyone involved in diagnosing or managing epilepsy.

Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches to squamous cell carcinomas of the head and neck. In recent years, great advances in translational research have lead to new treatment paradigms. This book covers such progress in a number of clinical settings including programs of organ and function preservation, curative treatments of unresectable disease, adjuvant treatments in high-risk patients, and palliative approaches for recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy and chemotherapy, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, treatment in the elderly, and socio-economic aspects. State-of-the-art functional imaging techniques are covered. The latest developments in high precision techniques in irradiation, sequencing treatments of chemo- and radiotherapy, as wells as the integration of biomolecular therapies into cytotoxic treatments are also explored.

Expanded to include detailed information on pharmacologic and non- pharmacologic treatment, this handbook continues to offer a concise overview of the field for trainees and practitioners in the many disciplines that deal with sleep disorders. Chapters provide a broad introduction to sleep disturbances and associated comorbidities and discuss the major sleep disorders in terms of epidemiology, diagnostic criteria, differential diagnosis, assessment tools, management, and follow-up. Of special value are algorithms that provide a logical approach to evaluating sleep- related complaints. All chapters adhere to the new International Classification of Sleep Disorders (ICSD-2), which is outlined in an appendix with ICD-9 codes.

Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Such neurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson's disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field. This volume emphasizes essential observations from all of the important clinical phases involved in any neuromodulation: targeting, intraoperative assessment, programming, complications, and complication avoidance. There are commonalities to all neuromodulation procedures that must be brought to the forefront to form a cohesive presentation of neuromodulation, and such emphasis will give readers a more solid grounding in the fundamentals needed to embrace this field as a cohesive clinical entity. * Chapters offer point-counterpoint commentary for varied perspectives* Appendix distills current guidelines in easy, accessible format* Chapters follow story of patient care, effectively emphasizing general principles with supporting examples* Offers outstanding scholarship, with over 20% of chapters involving international contributors

In this title, the classification of brain tumors is up-dated using magnetic resonance spectroscopy technology. The role of cellular immortality in brain tumors is reviewed. Tumor to tumor metastases are a common occurrence; for example, brain metastasis from breast cancer, lung cancer, and renal cancer is discussed. Genetic profiling and treatment (including neurosurgery) of such brain cancers are explained. Breast cancer patients treated with certain drugs (e.g., capecitabine and lapatinib can develop CNS tumors. Role of brain tumor suppressor genes (e.g., NRP/B gene) is pointed out. Biomarkers used to diagnose brain malignancies are explained in detail. A number of imaging modalities used for diagnosing and assessing the effectiveness of treatments of brain tumors are presented. The imaging methods discussed include MRI, PET, CT, MRSi, and SPECT. Also discussed is the impact of PET using radiolabeled amino acids on brain tumors.

Drs. Mary Ann Werz and Ignacio L. Pita present "Epilepsy Syndromes", a unique book with companion DVD that guides you through the difficult diagnostic challenges associated with this disorder. It is organized by epilepsy syndromes for easy reference, and the DVD shows patient videos running concurrently with their EEG tracings. It's the perfect tool for evaluating patients with seizures.

"Core Techniques in Operative Neurosurgery" provides step-by-step guidance to help you effectively manage the full range of cranial and spinal neurosurgical disorders. Drs. Rahul Jandial, Paul McCormick, and Peter Black offer their expertise and experience in consistent chapters that cover the indications and contraindications, pitfalls, tips and tricks, and more for each procedure. With access to the full text and procedural videos online, you'll have everything you need to minimize risk and get the best results.

The Handbook of Clinical Neurology Vol 100: Hyperkinetic Movement Disorders discusses hyperkinetic disorders related mainly to basal ganglia dysfunction and pathology. It contains 13 sections and 51 chapters written by authoritative and experienced investigators and clinicians in this extremely broad and diverse group of diseases and syndromes. The first section on choreoathetoid diseases and syndromes includes chapters on Huntington's disease and Huntington's disease look-alikes; spinocerebellar degenerations; neuroacanthocytosis; entatorubral-pallidoluysian atrophy; neuroferritinopathy; neurodegeneration with brain iron accumulation; mitochondrial disorders; acquired hepatocerebral degeneration; benign hereditary chorea; and "senile chorea. The remaining chapters focus on the abnormal involuntary movements associated with each disease or syndrome. These include immune-related chorea, vascular chorea, metabolic disturbances that can induce chorea, chorea in other medical settings (e.g., postpump chorea in children, cancer-related paraneoplastic syndromes), myoclonus, essential tremor, and dystonia, including dystonia plus syndromes. There are also chapters on tardive dyskinesia, unusual clinical syndromes, and tics and stereotyped movements in children. The text is a valuable resource for neurology and psychiatry residents, practicing neurologists and psychiatrists, and specialists in movement disorders. * An authoritative, comprehensive guide to movement disorders * An invaluable reference for the diagnosis and treatment of hyperkinetic diseases and syndromes * High-level discussions that are ideal for specialists in movement disorders, practitioners and residents alike

A large number of neurological conditions result in abnormal movements of the body; these are often characterized by changes in coordination and altered speed of voluntary movement. Many obscure diseases, conditions and environmental insults can cause movement disorders but these are often overlooked. This volume expands and differentiates the many varied clinical presentations of movement disorders. Written by an international team of authors, including some of the most prominent clinicians in the field, disorders are defined and expanded in a clinically useful manner. Pathophysiological theories, genetic discoveries, new classifications, differential diagnoses and therapies are discussed extensively. Uncommon Causes of Movement Disorders provides a broad and comprehensive review of the field, concentrating on conditions infrequently seen but essential for practitioners to recognize in order to implement appropriate management. This is a key text for movement disorders specialists and general neurologists at all stages of their career.

This is a practical guide and concise reference that can be a companion text for the general surgical pathologist, trainees in pathology and neuropathology, and clinicians who treat patients with neurological diseases that require surgical sampling.

Endovascular intervention - using medication and devices introduced through catheters or microcatheters placed into the blood vessels through a percutaneous approach - has emerged as a relatively new minimally invasive approach to treat cerebrovascular disease and possibly intracranial neoplasms. This textbook provides a comprehensive review of principles pertinent to endovascular treatment of cerebrovascular diseases and intracranial tumors, with a detailed description of techniques for these procedures and periprocedural management strategies. Particular emphasis is placed on expert interpretation of the quality of evidence provided and implications for practice related to endovascular procedures. This will be essential reading for clinicians working in interventional neurology and cardiology, endovascular neurosurgery, vascular surgery and neuroradiology.

Designed to provide a comprehensive but accessible introduction to epilepsy and seizure disorders, Adult Epilepsy provides state-of-the-art information in a concise format useful to a wide audience, from neurology residents to epilepsy fellows and practitioners. This illustrated guide to the assessment, diagnosis, and treatment of epilepsy is a valuable resource enabling clinicians to stay on top of the latest recommendations for best practice.