This volume provides a summary review of all recently published and ongoing research initiatives related to Tourette Syndrome. The latest research is presented in a clinical context, and controversial issues are fully discussed using an evidence-based approach. These issues include the prevalence of TS, the nature of the TS phenotype, the role of autoimmunity in the development of TS, the role of comorbidity in functional outcomes of TS patients, and approaches to identifying the TS gene/genes. Chapters describe recent advances in neuroimaging, genetics, and treatment. The book includes extensive discussions of co-morbid disorders: obsessive-compulsive disorder, attention deficit hyperactivity disorder, mood disorders, and tics.
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CLINICAL PHENOMENOLOGY Phenomenology and Natural History of Tics James F. Leckman CO-MORBID DISORDERS ADHD Martha Bridge Denckla Obsessive Compulsive Disorder Euripedes C. Miguel Mood and Behavioral Disorders Mary M. Robertson Tics Associated with Other Disorders Joseph Jankovic NEW FINDINGS IN BASIC NEUROSCIENCES Preclinical Models Relevant to TS Neal R. Swerdlow Neurobiology of Basal Ganglia and TS: Neuroanatomy John W. Mink Neurobiology of Basal Ganglia and TS: Neurotransmitters and Neurochemistry Roger L. Albin NEUROIMAGING AND NEUROPHYSIOLOGY Motor Cortex Inhibition Donald L. Gilbert Functional Neuroimaging of Tourette Syndrome: Advances and Future Directions Tracy Butler, Emily Stern, and David Silbersweig GENETICS AND MOLECULAR BIOLOGY OF TS A Genome-Wide Scan and Fine Mapping in Tourette Syndrome Families David L. Pauls Genetic Database; Family Studies; Best Estimate William M. McMahon, Cornelia L. Illmann, and Meghan M. McGinn Genes and TS: What Will They Tell Us? Scientific, Ethical, and Social Implications Nancy M.P. King IMMUNOLOGY AND TS Preclinical and Clinical Evidence of CNS Infectious Etiology Tanya K. Murphy PANDAS: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Overview of the Hypothesis Gavin Giovannoni Neuroimmunological Studies in TS and PANDAS Harvey S. Singer PANDAS: To Treat or Not to Treat? Robert A. King EPIDEMIOLOGY AND DEFINING THE PHENOTYPE Syndrome Definitions and Epidemiology Lawrence Scahill ADVANCES IN TREATMENT Treatment of Tics Leon S. Dure IV and Jennifer DeWolfe Pharmacological Treatment of ADHD and Tics Kenneth D. Gadow Treatment of Comorbid OCD, Mood, and Anxiety Disorders Barbara J. Coffey Pharmacological Treatment of Explosive Outbursts Cathy L. Budman Behavioral Therapy for Tic Suppression John Piacentini and Susanna Chang Behavioral Therapy: Other Interventions Douglas W. Woods Behavioral Neurosurgery Donald Malone Future and Alternative Therapies in Tourette's Syndrome Roger Kurlan
